Allele Frequency Distribution of the Canine Dopamine Receptor D4 Gene Exon 3 and 1 in 23 Breeds
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- ITO Hideyuki
- Laboratory of Animal Genetics, Gifu University
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- NARA Hidetoshi
- Laboratory of Animal Genetics, Gifu University
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- INOUE-MURAYAMA Miho
- Laboratory of Animal Genetics, Gifu University
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- SHIMADA Makoto K.
- Laboratory of Animal Genetics, Gifu University
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- KOSHIMURA Akiko
- Laboratory of Animal Genetics, Gifu University
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- UEDA Yuko
- Laboratory of Animal Genetics, Gifu University
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- KITAGAWA Hitoshi
- Laboratory of Veterinary Internal Medicine, Gifu University
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- TAKEUCHI Yukari
- Laboratory of Veterinary Ethology, The University of Tokyo
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- MORI Yuji
- Laboratory of Veterinary Ethology, The University of Tokyo
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- MURAYAMA Yuichi
- National Institute of Animal Health
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- MORITA Mitsuo
- Livestock Improvement Association of Japan, Inc.
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- IWASAKI Toshiroh
- Department of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology
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- ÔTA Katuaki
- Faculty of Agriculture, Shinshu University
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- TANABE Yuichi
- School of Veterinary Medicine, Azabu University
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- ITO Shin'ichi
- Laboratory of Animal Genetics, Gifu University
書誌事項
- タイトル別名
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- Allele Frequency Distribution of the Canine Dopamine Receptor D4 Gene Exon III and I in 23 Breeds
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抄録
Various canine breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of them are under genetic control. Although dopaminergic neurotransmission system is considered to affect animal behavior, little is known about related genes in canine. Relations between specific alleles in polymorphic regions of the dopamine receptor D4 gene (DRD4) and personality or psychiatric disorders have been reported in humans, and we first found polymorphism in exon III region of the gene in 4 canine breeds. In this study we surveyed allele frequency distribution in 23 breeds including a total of 1,535 unrelated individuals. In exon III, 8 alleles including a novel allele were identified. A group of breeds in which the alleles 447b, 498 and 549 were frequent tended toward high scores in aggression-related behavioral traits than that with frequent alleles 435 and 447a. Moreover, a polymorphism based on 24 bp insertion/deletion was found in exon I region for the first time in dogs. This information may be of use for candidate gene studies of behavioral variation in dogs.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 66 (7), 815-820, 2004
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424216064
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- NII論文ID
- 130000448498
- 110003960143
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD2cXnsV2qsL4%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 7054255
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- PubMed
- 15297753
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可