Effects of Chitin and Chitosan on Collagen Synthesis in Wound Healing

DOI Web Site Web Site PubMed 被引用文献2件 参考文献27件
  • KOJIMA Kazuo
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • OKAMOTO Yoshiharu
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • KOJIMA Kazuya
    Department of Veterinary Pathology II, Azabu University, School of Veterinary Medicine
  • MIYATAKE Katsuyuki
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • FUJISE Hiroshi
    Department of Veterinary Pathology II, Azabu University, School of Veterinary Medicine
  • SHIGEMASA Yoshihiro
    Department of Materials Science, Faculty of Engineering, Tottori University
  • MINAMI Saburo
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University

この論文をさがす

抄録

Collagen synthesis was evaluated by measuring prolyl hydroxylase (PHL) activity induced within rat granulation tissue by a polyester non-woven fabric (NWF, 1 × 1 cm, 0.6 mm in thickness) impregnated with a chitin or chitosan suspension ranging in concentration from 0.1 to 10 mg/ml. In addition, PHL activity induced in rat granulation tissue by a NWF impregnated with a phosphate buffer solution was examined as a control. The PHL activity in each group remained low until 4 days post-implantation (Day 4). However, in the 10 mg chitin group, the PHL activity increased rapidly without scatter of the data at Day 7 and remained at a plateau until Day 14. In other groups, PHL activity increased linearly until Day 14. The data varied widely at Day 7. Compared to chitosan, chitin at the higher concentration was found to induce stable collagen synthesis in the early wound healing process.<br>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (27)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ