培養中のBabesia gibsoniに対するArcangelisia flavaから得られたprotoberberine alkaloidsと20-hydroxyecdysoneの抗バベシア活性

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献1件 参考文献30件
  • SUBEKI
    Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
  • MATSUURA Hideyuki
    Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
  • TAKAHASHI Kosaku
    Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
  • YAMASAKI Masahiro
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
  • YAMATO Osamu
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
  • MAEDE Yoshimitsu
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
  • KATAKURA Ken
    Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
  • SUZUKI Mamoru
    Department of Parasitology, Gunma University School of Medicine
  • TRIMURNINGSIH
    Research and Development for Biology, Indonesian Institute of Sciences
  • CHAIRUL
    Research and Development for Biology, Indonesian Institute of Sciences
  • YOSHIHARA Teruhiko
    Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

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タイトル別名
  • Antibabesial Activity of Protoberberine Alkaloids and 20-Hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in Culture

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抄録

Bioassay-guided fractionation of the boiled extract from the stems of Arcangelisia flava led to the isolation of palmatine (1), berberine (2), jatrorrhizine (3), dihydroberberine (4) and 20-hydroxyecdysone (5). The chemical structures of these compounds were elucidated on the basis of their chemical and spectral evidence. The isolated compounds were evaluated for their growth inhibiting effects on Babesia gibsoni in culture for a week. Compounds (1-4) showed significant inhibitions at concentrations from 100 to 1.0 μg/ml, while compound 5 at a concentration of 100 μg/ml, only.<br>

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