Role of Gap Junctional Intercellular Communication (GJIC) through p38 and ERK1/2 Pathway in the Differentiation of Rat Neuronal Stem Cells

  • YANG Se-Ran
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • CHO Sung-Dae
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • AHN Nam-Shik
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • JUNG Ji-Won
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • PARK Joon-Suk
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • JO Eun-Hye
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • HWANG Jae-Woong
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • JUNG Ji-Youn
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • KIM Tae-Yung
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • YOON Byoung-Su
    Laboratory of Genetics, Department of Biology, College of Natural Science, Kyonggi University
  • LEE Bong-Hee
    Department of Anatomy and Neurobiology, College of Medicine, Institute of Medical Science, Cheju National University
  • KANG Kyung-Sun
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
  • LEE Yong-Soon
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University

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抄録

Gap junctional intercellular communications (GJIC) contributes to neural function in development and differentiation of CNS. In this study, we have investigated the expression of GJIC during the differentiation of neuronal stem cells and 12-Ø-tetradecanoylphorbol-13-acetate (TPA)-induced neuronal stem cell-derived cells from rat brain. During neuronal stem cell differentiation, expressions of Cx43 and 32 were increased for the duration of 72 hr, however the effect were decreased on the 7d. In the neuronal stem cell-derived cells, pretreatments with p38 MAP kinase inhibitor, SB203580, and MEK inhibitor, PD98059, could protect GJIC against TPA-induced inhibition of GJIC. Our data suggest that GJIC plays an important role during neuronal stem cell differentiation, and ERK1/2 and p38 MAP kinase signaling pathway may be closely related functionally to regulate gap junction in rat neuronal stem cell-derived cells.<br>

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