-
- NEO Sakurako
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
-
- KANSAKU Norio
- Laboratory of Animal Genetics and Breeding, School of Veterinary Medicine, Azabu University
-
- FURUICHI Mitsuru
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
-
- WATANABE Masashi
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
-
- HISAMATSU Sin
- Department of Environmental Chemistry, College of Environmental Health, Azabu University
-
- OHNO Koichi
- Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- HISASUE Masaharu
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
-
- TSUCHIYA Ryo
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
-
- YAMADA Takatsugu
- Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University
書誌事項
- タイトル別名
-
- Molecular Cloning of the Canine c-Met/HGF Receptor and Its Expression in Normal and Regenerated Liver
この論文をさがす
抄録
The c-Met proto-oncogene is the receptor for hepatocyte growth factor (HGF), which is a member of the tyrosine kinase family. Activation of the HGF/c-Met signal pathway leads to cell proliferation, motility, regeneration, and morphogenesis. In this study, the complete nucreotide sequence of complementary DNA (cDNA) of canine c-Met was cloned, and its distribution was determined in tissues. The canine c-Met cDNA clone had an open reading frame of 4419 bp that encoded a putative polypeptide of 1383 amino acids. The c-Met mRNA was expressed in a variety of canine tissues including peripheral blood mononuclear cells (PBMC), bone marrow, liver, kidney, lung, stomach, uterus, testis, thymus, lymph node, small intestine, colon, adrenal gland, thyroid gland, heart, muscle, skin, pancreas, ovary, prostate, spleen, fat, cerebrum, and cerebellum. In addition, the c-Met mRNA expression in normal and regenerated liver was examined. The levels of the mRNA increased 2-fold in regenerated liver compared to that found in normal liver, indicating that c-Met is involved in various functions including remodeling of canine hepatocytes.<br>
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 67 (5), 525-529, 2005
公益社団法人 日本獣医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681402238720
-
- NII論文ID
- 130000448251
- 110003963763
-
- NII書誌ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL書誌ID
- 7372080
-
- PubMed
- 15942139
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可