単色中性子線を新生仔マウスに照射したときの内耳の形態学的変化

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献1件 参考文献49件
  • NITTA Yumiko
    International Radiation Information Center, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • ARAKI Nobukazu
    Department of Histology and Cell Biology, Faculty of Medicine, Kagawa University
  • NITTA Kohsaku
    Ohtani Rehabilitation Hospital
  • HARADA Toshihide
    Department of Health Services Management, Hiroshima International University
  • ISHIZAKI Fumiko
    Hiroshima Prefectural College of Health Science
  • CHENG Weiping
    Department of Neurology, The First Affiliated Hospital, Heilongjiang University of Traditional Chinese Medicine
  • ANDO Juko
    Department of Education, Faculty of Letters, Keio University

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タイトル別名
  • Effect of Monoenergetic Neutron Irradiation on the Postnatal Development of the Cochlea in C3H/HeN Mice

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To investigate the toxic effect of neutrons at energies of approximately 1MeV on the ear, we exposed 7-day-old mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or 137Cs gamma rays, and assessed subsequent morphological changes in the inner ear by light and scanning electron microscopy. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti had disappeared by 72 hr post-irradiation, as a result of epithelial apoptosis observed 6 hr post-irradiation. Radiation could induce apoptotic cell death of the epithelium of the greater epithelial ridge at 3 or 4 days of age. Protruding structures were detected on the surface of the hair cells by 72 hr post-irradiation. The neutron-irradiation also caused the apoptotic cell death of epithelial cells at the nasal conchae, and subsequent acute otitis media continued until 10 weeks of age.<br>

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