馬の慢性蹄葉炎罹患蹄の再生性葉状層における基底膜領域に見られた片側性構築異常

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献1件 参考文献52件
  • KUWANO Atsutoshi
    Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association
  • UENO Takanori
    Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association
  • KATAYAMA Yoshinari
    Epizootic Research Station (Tochigi-branch), Equine Research Institute, Japan Racing Association
  • NISHIYAMA Toshio
    Department of Tissue Physiology, Tokyo University of Agriculture and Technology
  • ARAI Katsuhiko
    Department of Tissue Physiology, Tokyo University of Agriculture and Technology

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タイトル別名
  • Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis

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Between the laminar epidermis and the laminar dermis of laminar region (LR) in equine foot, it can be observed the basement membrane zone (BMZ), which is composed of a basement membrane and its accompaniments like the hemidesmosome and anchoring fibril. Alteration in the BMZ in equine laminitis is possibly related with not only development but also recovery outcome and recurrence of this disease. However, there is little known about the structure of the BMZ during the recovery phase of this disease. To assess the condition of the BMZ of LR affected by chronic laminitis, the tissue was examined in three cases at two weeks, four weeks and three months after the onset of laminitis, using pathological, immunohistochemical and electron microscopic techniques. Histologically in all laminitis cases, there was a regenerated laminar epidermis with proliferating keratinocytes between the Stratum medium and the dermis, but it included the undeveloped secondary epidermal laminae (ud-SELs) structure in one side of the primary epidermal laminae, especially in the part of the deep area of LR. Immunohistochemical results were positive for the anti-type IV collagen, anti-type VII collagen and anti-laminin 5 antibodies in the most BMZs. However, partial BMZs adjacent to the ud-SELs were negative for the anti-type VII collagen and anti-laminin 5 antibodies. Ultrastructurally, in the BMZ of the ud-SEL, the lamina densa and the lamina lucida were present. In contrast, the anchoring fibrils and the hemidesmosomes were either absent, or present at lower than normal levels. In conclusion, the present study indicated that the part of regenerated LR in chronic laminitis was not able to fully restore to construct the BMZ for a long time, especially in the unilateral side of laminar epidermis. It might be related with recurrence of this disease.<br>

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