犬のチロシン水酸化酵素遺伝子およびドーパミンβ水酸化酵素遺伝子 : その塩基配列、遺伝子多型、および5犬種における多様性

• TAKEUCHI Yukari

  Laboratory of Veterinary Ethology, The University of Tokyo

• HASHIZUME Chie

  Laboratory of Veterinary Ethology, The University of Tokyo

• CHON Esther Myung Ha

  University of California Davis, School of Veterinary Medicine

• MOMOZAWA Yukihide

  Laboratory of Veterinary Ethology, The University of Tokyo

• MASUDA Koji

  Laboratory of Veterinary Ethology, The University of Tokyo

• KIKUSUI Takefumi

  Laboratory of Veterinary Ethology, The University of Tokyo

• MORI Yuji

  Laboratory of Veterinary Ethology, The University of Tokyo

書誌事項

タイトル別名

• Canine Tyrosine Hydroxylase (TH) Gene and Dopamine .BETA.-Hydroxylase (DBH) Gene: Their Sequences, Genetic Polymorphisms, and Diversities among Five Different Dog Breeds
• Canine Tyrosine Hydroxylase (TH) Gene and Dopamine β-Hydroxylase (DBH) Gene: Their Sequences, Genetic Polymorphisms, and Diversities among Five Different Dog Breeds
• Canine Tyrosine Hydroxylase TH Gene and Dopamine ベータ Hydroxylase DBH Gene Their Sequences Genetic Polymorphisms and Diversities among Five Different Dog Breeds

抄録

Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine β -hydroxylase (DBH). As a first step to elucidate the genetic background of canine behavioral traits, we selected these genes as targets and sequenced these canine genes, and found that both were highly homologous with those of human beings. Then brain cDNAs derived from ten unrelated Beagles were used to search for polymorphisms in these genes. Four single nucleotide polymorphisms (SNPs) (C97T, G168A, G180A and C264T), one of which (C97T) will cause amino acid substitution in the TH gene, and two SNPs (C789A and A1819G), both of which will cause amino acid substitutions in the DBH gene were identified. The allelic frequencies among five dog breeds (47 Golden Retrievers, 41 Labrador Retrievers, 40 Malteses, 26 Miniature Schnauzers, and 39 Shibas) were examined and found to have significant variation between them with regards to all these SNPs, except for C97T in the TH gene and A1819G in the DBH gene. The polymorphisms of C97T and A1819G were found only in the Shiba. The present results suggest that the polymorphisms of the genes encoding catecholamine biosynthetic enzymes may become important markers for examining the genetic background of behavioral characteristics in dogs.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 67 (9), 861-867, 2005

  公益社団法人 日本獣医学会

キーワード

• breed difference
• DBH
• dog
• polymorphism
• TH

詳細情報

• CRID: 1390001206425884032
• NII論文ID: 110003983154
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.67.861
• COI: 1:CAS:528:DC%2BD2MXhtFKmsrfP
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 7488257
• PubMed: 16210796
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030733236
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7488257
• Web Site: http://www.jstage.jst.go.jp/article/jvms/67/9/67_9_861/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006036139
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可