Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes.
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- SHIMOJIMA Takahiro
- Department of Periodontology, Josai Dental University
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- MASHIMA Toru
- Department of Periodontology, Josai Dental University
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- HOBO Kiyohiko
- Department of Periodontology, Josai Dental University
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- KUSUNOKI Kimihito
- Department of Periodontology, Josai Dental University
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- MARUMOTO Yoshiko
- Department of Periodontology, Josai Dental University
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- IKEDA Katsumi
- Department of Periodontology, Josai Dental University
Bibliographic Information
- Other Title
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- Bacteroides gingivalisによる好中球のO2`-´産生におよぼすプロスタグランジンの影響
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Abstract
The effects of prostaglandin analogues (PGE1, E2, D2, I2) on superoxide (O-2) production by human polymorphonuclear leukocytes (PMN) stimulated by the supernatant of a B. gingivalis 381 sonicate (BGsup) were studied in vitro by a cytochrome C reduction method.<BR>O-2 production by the PMN was enhanced distinctly by the BG-sup and this increased O-2 production was nullified by the addition of PGE1, E2, or D2 at a concentration of 0.02ug/ml. However, PGI2, even at a concentration of 2ug/ml, could not bring down the O-2 production.<BR>The amount of intracellular cyclic AMP (cAMP) of PMN treated with these PG were measured; and the results indicated all of these PG caused on elevation of the cAMP level.<BR>The effect of dibutyryl cAMP, an analogue of cAMP, on O-2 production was also examined, and almost the same results were obtained as with the PG.<BR>These results suggest that the reduction in B. gingivalis-induced O-2 production by PMN that occurred by addition of PG was due to the increase in intracellular cAMP; that is, cAMP appears to suppress the O-2 production augmented by the BG-sup.
Journal
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- Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
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Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 29 (2), 454-462, 1987
JAPANESE SOCIETY OF PERIODONTOLOGY
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Details 詳細情報について
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- CRID
- 1390001204411273344
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- NII Article ID
- 110003989045
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- NII Book ID
- AN0019129X
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- ISSN
- 1880408X
- 03850110
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- PubMed
- 2851629
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed