歯垢からの Siderophore 産生菌検出

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  • Isolation of Siderophore Producing Microorganisms from Dental Plaques

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Iron is an essential element for growth of almost all pathogenic and nonpathogenic microorganisms. However, the concentration of free iron in the mammals body is very low, because, most of the iron is either stored intracellularly or bound to proteins, such as transferrin in plasma and lactoferrin in mucosal secretions and heme proteins. Many bacteria have developed ingenious systems to transport iron from the host into the cells; one mechanism employs a siderophore-mediated iron transport system. However, little is known about the distribution or isolation of siderophore-producing microorganisms in the human dental plaques. Herein, the isolation and distribution of siderophore-producing bacteria in human dental plaque were examined. Siderphore-producing bacteria were detected in 3 out of 10 samples from healthy volunteers, and in 37 out of 50 samples from patients with gingivitis. Siderophore-producing bacteria isolated from dental plaque were identificated as Citrobacter diversus Enterobacter gergoviae, Enterobacter cloacae and Enterobacter amnigenus, respectively. A siderophore produced by Enterobacter gergoviae enhanced the growth of Porphromonas gingivalis strain W 83,but not that of strain ATCC 33277 in iron limited medium. These findings suggest that siderophore producing microorganisms in the dental plaques, such as Enterobacteriaceae, are involved in the aggravation of periodontal diseases and damage periodontal tissues.

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