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- 木村 博
- 福岡大学医学部薬理学教室
書誌事項
- タイトル別名
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- Suppressive Effects of Kambaku-taiso-to on the Yawning Induced by Cholinergic Agonists.
- カンバク タイソウトウ ニ ヨル コリン サドウセイ ユウハツアクビ コウドウ
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抄録
The present experiments were performed to investigate effects of a Kampo (Japanese herbal) medicine, Kambaku-taiso-to (Gan-mai-da-zao-tang), on incidence of yawning in rats. Physostigmine, a cholinesterase inhibitor, 0.05-0.1mg/kg s. c., induced yawning responses with a marked effect at 0.05mg/kg. Pilocarpine, a muscarinic receptor agonist, 1-2mg/kg s. c., also induced yawning responses, the maximum effect being observed at a dose of 2mg/kg. Talipexole, a dopaminergic D-2 receptor agonist, 0.02mg/kg s. c., also induced yawning. Kambaku-taiso-to, 250-1, 000mg/kg, was orally administered 30min before injection of physostigmine, pilocarpine or talipexole. The yawning induced by both cholinergic and dopaminergic agents was reduced in a dose-dependent manner by Kambaku-taiso-to. All the yawning responses to cholinergic and dopaminergic agents were also reduced by rauwolscine 0.5mg/kg, yohimbine 2.5mg/kg, α-2 adrenoceptor antagonists, and by scopolamine 0.5mg/kg—muscarinic receptor antagonist. The present findings thus suggest that Kambaku-taiso-to exerts a suppressive effect on the incidence of yawning, and dopaminergic and cholinergic suppression and the indirect suppressive mechanism mediated by the central adrenergic nerve are associated with this suppression.
収録刊行物
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- 日本東洋医学雑誌
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日本東洋医学雑誌 49 (1), 11-19, 1998
一般社団法人 日本東洋医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679885729664
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- NII論文ID
- 110004000977
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- NII書誌ID
- AN00015774
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- ISSN
- 1882756X
- 02874857
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- NDL書誌ID
- 4498363
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可