加齢に伴うマウスの小腸粘膜の変化に対する漢方薬の作用 : 六君子湯, 補中益気湯, 人参養栄湯, 半夏瀉心湯エキス剤の作用  [in Japanese] Effects of Kampo Medicine Extracts on Morphological Changes in the Small Intestinal Mucosa of Mice with Age  [in Japanese]

加齢に伴う小腸粘膜形態の変化に対する六君子湯, 補中益気湯, 人参養栄湯, 半夏瀉心湯の影響を検討した。その結果, 36週齢ラットの小腸粘膜の変化には六君子湯, 補中益気湯のような補気健脾剤が有効で, 特に絨毛と微絨毛の吸収面積の改善には濃度依存性が認められた。ところが, 50週齢, 70週齢のより高齢のマウスに対しては人参養栄湯のような気血双補剤が有効で, 小腸の形態及び吸収機能が著明に改善されることが明らかになった。

The effects of Rikkunshi-to (Liu jun zi tang), Hochu-ekki-to (Bu zhong yi qi tang), and Hange-shashin-to (Ban xia xie xin tang) on morphological changes in the small intestinal mucosa of mice with age were observed. The results indicated that Rikkunshi-to and Hochu-ekki-to had a beneficial effect on intestinal mucosal changes in 36-weeks-old mice. In particular, the improvement of the absorptive area of the intestinal villi and microvilli depending on the concentration of medicine was found. Ninjin-yoei-to had a strong effect on aged mice of 50 and 70 weeks. The morphology and absorptive function were significantly improved.