Biology of the Extracellular Matrix Tenascin-C :

• SAKAKURA,Teruyo

  Department of Pathology, Mie University School of Medicine

• YOSHIDA,Toshimichi

  Department of Pathology, Mie University School of Medicine

抄録

Tenascin was initially found to be an oncofetal type of extracellular matrix glycoprotein which is produced by the mesenchyme. The TN-gene family comprises the three distinct genes, TN / cytotactin(TN-C), J1-160 / 180 / janusin / restrictin(TN-R), and TN-MHC / XB / p450opp(TN-X). In mouse mammary glands, both immunoreactive TN-C and TN-C mRNA are demonstrated in the dense mesenchyme surrounding the embryonic mammary buds, growing end buds, and tumors. While in the epithelium, TN-C mRNA is expressed at the embryonic stage and tumors. In human breast cancers, TN-C is related to the prognosis. The positive staining in the cancer stroma is unfavorable and that in the cancer cells is much worse. For the biological functions of TN-C, we propose an anti-adhesion / counter adhesion and cancer cell growth promotion in collaboration with FN. In wound closure assay, TN-C stimulates the migration of the cancer cells cultured on the FN-coating plate. And in cancer cell growth assay, TN-C stimulates the proliferation of cancer cells cultured on FN-coating plates in dose-dependent manner.

収録刊行物

• Connective tissue

  Connective tissue 31 (4), 221-225, 1999-12-25

  日本結合組織学会

キーワード

• tenascin
• fibronectin
• mammary gland
• cancer cell migration
• cell proliferation

詳細情報

• CRID: 1540854195346716544
• NII論文ID: 110004002274
• NII書誌ID: AN10169901
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/11084760
• Web Site: https://search.jamas.or.jp/link/ui/2000165347
• 本文言語コード: en
• データソース種別:
  • NDL-Digital
  • CiNii Articles