周期性好中球減少症家系にみられた早期発症型歯周炎の症例研究 : 1.発端者および父親の歯周炎の病態 Case reports of a family manifesting early-onset periodontitis associated with cyclic neutropenia : 1.Early-onset periodontitis in the proband and his father

Cyclic neutropenia is a rare blood disease characterized by regular 21-day cyclic fluctuations in the numbers of blood neutrophils. Periodontal diseases associated with cyclic neutropenia in members of a family manifesting cyclic neutropenia were studied to determine the roles of neutrophil function in the onset and progression of peridontal disease. The proband (11-yr-old boy) manifested a localized form of early-onset, rapidly progressive periodontitis with severe gingival swelling and inflammation which showed resistance to mechanical and chemical plaque control. His father had episodes of symptoms associated with cyclic neutropenia and early-onset periodontitis. He has been edentulous since the age of 23 due to spontaneous tooth loss. It is concluded that the absence of neutrophils might play a central role in the onset, progression and resistance to treatment of early-onset periodontitis with cyclic neutropenia by allowing opportunistic infection in the periodontal tissues.