キシリトールのプラーク沈着抑制効果に関する研究  [in Japanese] Inhibitory Effect of Xylitol on de novo Plaque Formation  [in Japanese]

キシリトール配合製品と溶液,クロルヘキシジンを混合したキシリトール溶液のプラーク沈着抑制効果を比較した。健康な成人10名を被験者とした。材料は蒸留水(DW),65% キシリトール配合ガム(XG),100% キシリトール含有キャンディー(XC),5% キシリトール溶液(5% X),20% キシリトール溶液(20% X),5% キシリトール溶液と0.02%クロルヘキシジンの混合液(XCHX)を用いた。実験開始前,14日間にわたり専門家による歯面清掃(PTC)と口腔衛生指導を行った。実験開始時から全ての機械的歯面清掃を中止し,XG または XC の場合は1日2回,2個ずつ摂取するように,溶液の場合は10mlでl日2回1分間の洗口を行うよう指示した。実験開始時と4日後に診査した(Plaque lndex)。診査後PTCと被験者自身によるブラッシングを再開し,10日後再ぴ歯面清掃を中止し,XGまたはXCの使用,または洗口を4日間行った。以上を6回繰り返した。DW と 5% X の間(p<0.05),DW と 20% X の間(p<0.05),DWとXCHXとの問(p<0.01)に有意差が認められた。XGとXCによるプラーク沈着抑制効果はDWよりやや優れているが,有意差はなかった。5% X と20% X の使用により有意なプラーク抑制効果がみられた。キシリトール溶液にクロルヘキシジン溶液を混合することによりプラーク沈着効果が高まった。結論として,高濃度のキシリトール溶液とクロルヘキシジンを混合することによりプラークの形成抑制効果が高まるので,このような形での使用が歯周病や幅蝕の予防に有効であると思われる。

An inhibitory effect of xylitol-containing preparation or solution at different concentrations with or without chlorhexidine on de novo plaque formation was clinically compared. Ten adult subjects aged 26-34 years old with apparently healthy gingiva showing no sign of periodontal disease were enrolled in this study. Test materials examined this study were : 1) distilled water (negative control) (DW) , 2) 65% xylitol combined chewing gum (Xly-fresh^<[O!R]>) (XG), 3) 100% xylitol candy (XYROFIN^<[O!R]>) (XC), 4) 5% xylitol solution (5% X), 5) 20% xylitol solution (20% X) and 6) 50% xylitol solution mixed wiith 0.02% chlorhex-idine (XCHX). For 14 consecutive days prior to the experiment, tooth surface cleaning and oral hygiene instruction were performed by a dentist. All mechanical tooth cleaning were abstained at the beginning of experiment. During the study period, the subjects were instructed to chew or suck 2 xylitol combined gums or candies a time, twice a day (total 4 gums or candies) , or to rinse with 10 of DW or xylitol solution twice a day for 1 minute each. At the beginning of experiment and again on Day 4, all tooth surface was examined by Silness Loe's plaque index (P1I). After examination on Day 4, tooth cleaning by the dentist and brushing by the subject were restarted followed, both of which were again stopped after 10 days and chewing a gum or sucking a candy or rinsing the mouth was performed for subsequent 4 days. This sequential procedure was repeated 6 times for each of xylitol-containing preparations and solution mentioned above. A statistical significant difference was observed between DW and 5%o X or 20% X (p< O.05) as well as between DW and XCHX (p<0.01). From this study, the following conclusions could be drawn : 1) The inhibitory effect of xylitol-containing chewing gum and candy on de novo plaque formation was revealed to be slightly better to that of the control group but the difference showed no statistical significance. 2) A significant inhibitory effect on de novo plaque formation was observed with use of 50% and 20%o Xylitol solution. 3) Through addition of 0.02% chlorhexidine to 5% xylitol solution, the inhibitory effect on de novo plaque formation was reinforced. In conclusion, the higher percentage of xylitol solution mixed with chlorhexidine may effective for preventing periodontal desease and caries lesion. J. Jpn. Soc. Periodontol., 43 : 289-294, 2001.