スナネズミのＨｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉ胃内定着と口腔内における菌の検出に関する研究

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  • Studies on Helicobacter pylori Colonization in the Stomach of Mongolian Gerbils and Detection of Bacteria in the Oral Cavity.

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Advances in research on the relationship between Helicobacter Pylori and gastric mucosa disease and H. pylon infection from oral cavities is promising, but raises the problem of H. pylon presence in the oral cavities and its influence on periodontitis. We studied the existence of H. pylori in the oral cavity of Mongolian gerbils infected with H. pylon in the stomach using the polymerase chain reaction.<BR>H. Pylori was not detected in the oral cavities just after the administration of H. pylon in the stomach, and although H. pylori was detected from the tongue on day 60 after infection in the stomach, it was not detected from the mandibula on day 120. H. Pylori was not detected from the maxilla until day 120. The number of H. pylon in the stomach was decreased by oral administration of Chinese medicine, dai-shi-koto. In drug treatment, H. pylon was not found from the tongue sample, but was found in the sample of mandibula after drug treatment.<BR>Although H. pylon was not colonized directly in the oral cavity, it was assumed that H. pylori existed in the counterflow from the stomach. Because H. pylon was detected from mandibula after decrease in the number in the stomach, the possibility of H. pylon in the counterflow and its fixation in the oral cavity was suggested. J. Jpn. Soc. Periodontol., 43 : 353-360, 2001.

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