Endothelin-1 Receptor Antagonist BQ123 Prevents Pulmonary Artery Hypertension Induced by Low Ambient Temperature in Broilers

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  • Yang Ying
    Division of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University
  • Qiao Jian
    Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University
  • Wu Zhenlong
    Department of Animal Physiology, College of Biological Sciences, China Agricultural University
  • Chen Yue
    National Natural Science Foundation of China
  • Gao Mingyu
    Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University
  • Ou Deyuan
    Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University
  • Wang Huiyu
    Division of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

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Abstract

Evidence has indicated that endothelin-1 is related to the pathogenesis of hypertension. To characterize the role of endothelin-1 (ET-1) in the development of pulmonary hypertension syndrome in broilers, the blockade effect of ETA receptor (ETA) antagonist, BQ123, on blood pressure in experimental models of pulmonary hypertension was examined. Birds were locally anesthetized and instrumented with venous catheters for pulmonary arterial pressure (PAP) and right ventricular pressure (RVP), followed by packed cell volume (PCV) and Ascites heart index (AHI) measured, after exposed to low ambient temperature for 7 or 14 d. In treated groups, BQ123 (0.4 or 2.0 μg/kg each time, 2 times a day), administered in abdominal cavities for 7 or 14 d during birds kept in low ambient temperature, prevented both PAP and RVP increasing, especially the high dose BQ123 lowered PAP and RVP to normotensive levels as that in control under normal temperature, whereas significant increases (p<0.05) were found in the two parameters of broilers in both untreated and saline treated group under low ambient temperature compared with those of birds in control. Furthermore, there was also a reduction in low ambient temperature-induced right ventricular hypertrophy in the groups administered BQ123. The preventive effect of BQ123 suggests that ET-1 is associated with the development of broilers' pulmonary hypertension, which leads to the development of ascites, and BQ123 can prevent the occurrence of pulmonary hypertension.

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