Taltirelin Improves Motor Ataxia Independently of Monoamine Levels in Rolling Mouse Nagoya, a Model of Spinocerebellar Atrophy
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- Nakamura Tomoka
- Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- Honda Motoko
- Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- Kimura Satoko
- Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- Tanabe Mitsuo
- Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- Oda Sen-ichi
- Laboratory of Animal Management and Resources, Division of Biosphere Resource Sciences, Nagoya University Graduate School of Bioagricultural Sciences
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- Ono Hideki
- Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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To examine the relationship between motor ataxia and monoamine levels in the central nervous system, the contents and concentrations of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the cerebellum, brain stem and spinal cord were measured in rolling mouse Nagoya (RMN), a murine model of spinocerebellar atrophy. The tissue weight of the cerebellum and spinal cord, but not that of the brain stem was significantly lower in RMN than in the control group. In RMN, the NA content of the brain stem and spinal cord, but not the cerebellum were decreased relative to the control, and the concentration of NA in the spinal cord was also lower, but not significant. The DA and 5-HT contents in each tissue did not differ from those of the control, but the concentrations of monoamines, except for DA, were elevated in the brain stem and spinal cord in RMN. In particular, the concentrations of NA, DA and 5-HT in the cerebellum were significantly increased in RMN. Repeated administration of tartilerin hydrate, an analog of thyrotropin-releasing hormone, improved the ataxia of RMN, and elicited no obvious changes in either monoamine content or concentration of cerebellum, brain stem and spinal cord. These results indicate that the concentration of DA, as well as NA and 5-HT, increased in the RMN cerebellum, and that tartilerin improves the motor function of these mice via mechanisms other than changes in the levels of NA, DA and 5-HT in the central nervous system.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (12), 2244-2247, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601298560
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- NII論文ID
- 110004049124
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7720894
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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