Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble β-Glucan: SCG

• Harada Toshie

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science

• Masuda Susumu

  Kikkoman Co.

• Arii Masayuki

  Kikkoman Co.

• Adachi Yoshiyuki

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science

• Nakajima Mitsuhiro

  Minahealth Co., Ltd.

• Yadomae Toshiro

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science

• Ohno Naohito

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science

書誌事項

タイトル別名

• Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble .BETA.-Glucan: SCG
• Soy Isoflavone Aglycone Modulates A Hematopoietic Response in Combination with Soluble ベータ Glucan SCG

抄録

Soy isoflavone aglycones (IFAs) have a wide range of biological actions that suggest they may be of use in cancer prevention. On the other hand, a branched β-glucan from Sparassis crispa (SCG) is a major 6-branched 1,3-β-D-glucan in an edible/medicinal mushroom: Sparassis crispa showing antitumor activity. We have previously reported that both oral and intraperitoneal administration of SCG enhanced the hematopoietic response in cyclophosphamide (CY)-induced leukopenic mice. In this study, we investigated the hematopoietic response due to IFA in combination with SCG in CY-induced leukopenic mice. The oral administration of IFA in combination with SCG synergistically enhanced the number of white blood cells, and increased spleen weight. Analyzing the leukocyte population by flow cytometry, the combination of IFA and SCG increased the number of monocytes and granulocytes in the spleen. Taken together, the combination of IFA and SCG synergistically provides the hematopoietic responses that are enhanced over IFA or SCG alone.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (12), 2342-2345, 2005

  公益社団法人 日本薬学会

キーワード

• soy isoflavone aglycone
• β-glucan
• branched β-glucan from <i>Sparassis crispa</i> (SCG)
• hematopoietic response

詳細情報

• CRID: 1390001204624838016
• NII論文ID: 110004049145
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.2342
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7721301
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7721301
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/12/28_12_2342/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006248224
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可