Quinone Derivatives by Chemical Transformations of 16-Hydroxycarnosol from Salvia Species
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- Marrero Joaquín González
- Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna
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- Andrés Lucía San
- Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna
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- Luis Javier Gutiérrez
- Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna
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The known diterpenes 12,16-epoxycarnosol (2), isotanshinone II (6), and (+)-neocryptotanshinone (8) were obtained by partial synthesis from 16-hydroxycarnosol (1), a C-16 hydroxylated abietatriene diterpene isolated in relative abundance from the aerial part of Salvia mellifera GREENE. The physical and spectroscopic data of these semisynthetic diterpenes were identical to those given for the natural ones in the literature. These abietane diterpenes have very interesting biological activities and the semisynthetic approach described here represents an alternative to obtain them from other major diterpenes isolated from Salvia species. Additionally, seven new semisynthetic diterpene analogues, 11,14-dioxo-12,16-epoxy-8,12-abietadien-20,7β-olide (3), 11,14-dioxo-12,16-epoxy-8,12,15(16)-abietatrien-20,7β-olide (4), 15,16-didehydro-12,16-epoxycarnosol (5), 1-oxoisotanshinone II (7), 16-hydroxycolumbaridione (9), 12,16-diacetoxycolumbaridione (10), and 14-methoxy-12,16-epoxycarnosol (13), were obtained from 1. The structures of the new compounds were established based on their spectroscopic data.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 53 (12), 1524-1529, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679145307008
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- NII論文ID
- 110004049469
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 7720681
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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