Three New Podocarpane-Type Diterpenoids from Callus of Securinega suffruticosa

    • Yuan Wei YUAN Wei
    • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
    • Lu Ziming LU Ziming
    • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
    • MENG Chao
    • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
    • CHENG Ke di
    • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
    • ZHU Ping
    • Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

Three new podocarpane-type diterpenoids, 3β, 12-dihydroxy-13-methyl-6, 8, 11, 13-podocarpatetraen (1), 3β, 12-dihydroxy-13-methyl-5, 8, 11, 13-podocarpatetraen-7-one (2), and 1-(7-hydroxy-2, 6-dimethyl-1-naphthyl)-4-methyl-3-pentanone (3) (20(10→5)-abeo-4, 5-seco-5(10), 6, 8, 11, 13-podocarpapentaen-3-one) were isolated from callus of Securinega suffruticosa. The structures were elucidated by spectroscopic methods. Compounds 1, 2, and 3 showed cytotoxic activity against five human cancer cell lines (A549, BEL 7402, BGC-823, HCT-8, A2780).

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(12), 1610-1612, 2005-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  14

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Codes

  • NII Article ID (NAID) :
    110004049489
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    7721123
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.53.1610
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE 

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