Cellular Automaton Model of a Tumor Tissue Consisting of Tumor Cells, Cytotoxic T Lymphocytes (CTLs), and Cytokine Produced by CTLs (特集:第11回MPSシンポジウム--複雑系の科学とその応用) Cellular Automaton Model of a Tumor Tissue Consisting of Tumor Cells, Cytotoxic T Lymphocytes (CTLs), and Cytokine Produced by CTLs (Cellular Automata, <Special Issue>MPS Symposium 2004 "Complex System Science and its Application")

We propose a cellular automaton model of a tumor tissue consisting of a square lattice, tumor cells, cytotoxic T lymphocytes (CTLs) and cytokine. Considering that CTLs circulate in vivo and migrate into a tumor tissue, the square is open and CTLs move through the square. By calculating the cellular automaton model, we obtained these results : the growth of a mass of tumor cells surrounded by CTLs : the rejection of tumor cells by CTLs; and an approximate equilibrium between tumor cells and CTLs. Analysis of the results indicates that the attachment between tumor cells and CTLs is important for the rejection of tumor cells by CTLs.