N-置換およびN,N-二置換2,4-dihydroxythiobenzamide類の合成, 抗菌活性および構造活性相関

• Niewiadomy Andrzej

  Department of Chemistry, University of Agriculture

• Matysiak Joanna

  Department of Chemistry, University of Agriculture

• Fekner Zygmunt

  Department of Analytical Chemistry, M. Curie-Skłodowska University

• Czeczko Renata

  Department of Chemistry, University of Agriculture

書誌事項

タイトル別名

• Synthesis, antifungal activity and SAR of N-substituted and N,N-disubstituted 2,4-dihydroxythiobenzamides

抄録

N-Substituted and N,N-disubstituted 2,4-dihydroxythiobenzamides were synthesized and their fungistatic properties were examined. The compounds were prepared by reacting sulfinyl-bis-(2,4-dihydroxythiobenzoyl) with primary or secondary amines. The activities of the derivatives against five phytopathogenic fungi were measured in vitro. The growth-inhibitory activity of these compounds depends mainly on their lipophilicity. Parabolic relationships between growth-inhibitory activity and lipophilicity (calculated n-octanol-water partition coefficient and log k_w from reversed phase chromatography) were found. The influence of the type of N-substitution on the character of the thioamide bond was analyzed based on ¹H NMR, MS and IR spectra. © Pesticide Science Society of Japan

収録刊行物

• 日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ）

  日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ） 31 (1), 14-22, 2006

  日本農薬学会

キーワード

• 2,4-dihydroxythiobenzamides
• growth-inhibitory activity
• phytopathogenic fungi
• lipophilicity
• structure-activity

詳細情報

• CRID: 1390001205209478656
• NII論文ID: 110004085891
• NII論文ID: 130004445009
• NII書誌ID: AA11818622
• DOI: 10.1584/jpestics.31.14
• ISSN: 13490923
• ISSN: 03851559
• ISSN: 1348589X
• NDL書誌ID: 7850048
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7850048
• Web Site: http://www.jstage.jst.go.jp/article/jpestics/31/1/31_1_14/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10877729
• 本文言語コード: en
• データソース種別:
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