Sensitivity of Serotonin Synthesis to Synthesis Inhibitor GTP Cyclohydrolase I in Senescence-Accelerated Mouse-Prone Inbred Strain (SAMP8)

• Karasawa Nobuyuki

  Faculty of Care and Rehabilitation, Seijoh University

• Watanabe Kazuko

  Department of Physiology, Gifu University, School of Medicine

• Yamada Keiki

  Department of Anatomy, School of Health Sciences

• Nagatsu Ikuko

  Department of Anatomy, School of Medicine, Fujita Health University

• Onozuka Minoru

  Department of Physiology and Neuroscience, Kanagawa Dental College

抄録

To study the relationship between aging and levels of monoaminergic neurons, 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of monoamine synthesis, was intraperitoneally administered to senescence-accelerated mouse-prone (SAMP8) mice. Time course of immunoreactive intensity for serotonergic (5-HT) neurons in the dorsal raphe nucleus, which were stained using laboratory-raised serotonin-specific antibody, was quantitatively evaluated using an image analysis system. Results showed that 5-HT neurons are not highly sensitive to a synthesis inhibitor common to both catecholaminergic and 5-HT neurons.<br>

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 38 (6), 367-371, 2005

  日本組織細胞化学会

キーワード

• aging
• serotonin
• immunohistochemistry
• 2,4-diamino-6-hydroxypyridine
• senescence-accelerated mouse-prone (SAMP8)

詳細情報

• CRID: 1390282679839110016
• NII論文ID: 110004101541
• NII書誌ID: AA00508022
• DOI: 10.1267/ahc.38.367
• ISSN: 13475800
• ISSN: 00445991
• Web Site: http://www.jstage.jst.go.jp/article/ahc/38/6/38_6_367/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10804927
• Web Site: https://search.jamas.or.jp/link/ui/2006295717
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可