The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle

• Oguma Tetsuya

• Kume Hiroaki

• Ishikawa Takayuki

• Ito Satoru

• Kondo Masashi

• Honjo Haruo

• Kamiya Kaichiro

• Shimokata Kaoru

抄録

To determine whether a reduction in the sensitivity to Ca^2+ is involved in relaxation by β-adrenergic receptor agonists, we examined correlation between force generation and intracellular Ca^2+ concentration in the inhibitory effects of isoproterenol (ISO) on methacholine (MCh)-induced contraction. Fura-2 was loaded in tracheal smooth muscle of guinea pigs and tension and fluorescence ratio F_<340>/F_<380> as an index of intracellular Ca^2+ concentration were recorded simultaneously. Addition of 0.3 μM ISO caused an inhibition in 1 μM MCh-induced contraction and a reduction in intracellular Ca^2+ concentration. The reduction in intracellular Ca^2+ concentration was, however, much smaller than that of tension. In conclusion, Ca^2+ sensitivity in addition to Ca^2+ influx plays an important role in β-adrenergic action in airway smooth muscle.

収録刊行物

• Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

  Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 47 59-61, 2003-12

  Research Institute of Environmental Medicine, Nagoya University

キーワード

• calcium sensitivity
• beta-adrenergic agonists
• smooth muscle
• isoproterenol

詳細情報

• CRID: 1390009224404185856
• NII論文ID: 110004322467
• NII書誌ID: AA1051621X
• DOI: 10.18999/envm.47.59
• HANDLE: 2237/7593
• ISSN: 02870517
• Web Site: https://nagoya.repo.nii.ac.jp/records/5976
• Web Site: https://search.jamas.or.jp/link/ui/2005108804
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles
• 抄録ライセンスフラグ: 使用可