p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct
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The purpose of this study is to clarify whether or not p53 gene mutations differ between gallbladder carcinoma (GBC) with an anomalous junction of the pancreaticobiliary duct (AJPBD) and GBC without AJPBD. We examined 17 GBCs with AJPBD and 22 GBCs without AJPBD. Immunohistochemically, the frequency of p53 protein over-expression was 64.7% in GBCs with AJPBD and 77.3% in GBCs without AJPBD. p53 mutations were found in 47.1% of GBCs with AJPBD and 50.0% of GBCs without AJPBD. The mutations were distributed from exons 5 to 8 without a preponderance in certain exons or specific mutational hot spots in either group. All mutations of GBCs with AJPBD were G : C to A : T transition, and 27.3% occurred at the CpG site. For GBCs without AJPBD, 30.3% of mutations were transversion, and mutations did not occur at the CpG site. These results indicate differences in the mutagenesis of p53 gene alteration between GBCs with AJPBD and GBCs without AJPBD.
収録刊行物
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- Acta medica et biologica
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Acta medica et biologica 50 (2), 83-90, 2002-06
Niigata University School of Medicine
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詳細情報 詳細情報について
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- CRID
- 1050282814205132928
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- NII論文ID
- 110004461740
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- NII書誌ID
- AA00508361
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- ISSN
- 05677734
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- HANDLE
- 10191/1911
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- CiNii Articles