Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides
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- Yutaka Tajima
- Clinical Laboratory, Saga Medical School Hospital
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- Jutaro Tadano
- Clinical Laboratory,Saga Medical School Hospital
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抄録
We examined the denaturing effects of deoxycholate and estrogen-3-monosulfate on antithrombin III (AT III) in vitro. These compounds reduced in parallel both the immunological and anticoagulant activity of AT III at high concentrations, and such denaturing effects were considered to be due to their detergent-like effect. These compounds made AT III heat-labile and reduced the affinity of AT III to sulfated polysaccharides such as heparin attached to agarose gel at lower concentrations, which showed no direct denaturation yet. These results indicate that such compounds bind to a lipophilic portion, which may be involved with the function of AT III.
収録刊行物
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- Acta medica et biologica
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Acta medica et biologica 41 (1), 25-31, 1993-03
新潟大学
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詳細情報 詳細情報について
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- CRID
- 1573950401746286464
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- NII論文ID
- 110004461799
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- NII書誌ID
- AA00508361
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- ISSN
- 05677734
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles