3) 抗甲状腺ホルモン自己抗体を有した慢性甲状腺炎の1例(シンポジウム 甲状腺疾患の臨床, 第469回新潟医学会)

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タイトル別名
  • Chronic Thyroiditis with Autoantibodies to T_3 and T_4(Clinic of the Thyroid Disease)

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抄録

A 52 years old female visited to our clinic in 1980 and then her serum levels of T_3 and T_4 were 0.6ng/ml and 1.9μg/dl, respectively, and her titer of thyroid test was 640^2. She was diagnosed as a patient with hypothyroidism due to chronic thyroiditis and given a thyroid replacement therapy. In 1984, her serum levels of T_3 and T_4 were 2.4ng/ml and 12.0μg/dl, respectively. Her serum levels of T_3 and free T_4 were beyond normal ranges and her serum titer of anti-TSH receptor antibody (TBII) was 5%, she was diagnosed to have a Hashitoxicosis and given thyuragyl. On August 1987, her serum level of TSH was 20.2μU/ml, although those of T_3 and T_4 were 3.2ng/ml and 27.0μg/dl, respectively. After PEG treatment, those of T_3 and T_4 were 1.6ng/ml and 3.4μg/dl, respectively, and her serum titers of anti-T_3 antibody and anti-T_4 antibody were positive (60.2% and 67.5%, respectively). In 1991, she had hypersweating and palpitation and was diagnosed to have Graves' disease because her serum TSH level was under 0.1uU/ml and her serum titer of TBII was 45.7%. She seemed a patient with autoimmune thyroid diseases, accompained with antibodies to T_3, T_4 and TSH receptor.

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