The Optimal Cut-off Point of C-Reactive Protein as an Optional Component of Metabolic Syndrome in Japan

• Oda Eiji

  Department of Internal Medicine, Niigata Prefectural Yoshida Hospital

• Oohara Kazuhiko

  Department of Internal Medicine, Niigata Prefectural Yoshida Hospital

• Abe Akihiro

  Department of Internal Medicine, Niigata Prefectural Yoshida Hospital

• Veeraveedu Punniyakoti T

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Watanabe Kenichi

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Kato Kiminori

  Division of Cardiology, Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science

• Aizawa Yoshifusa

  Division of Cardiology, Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science

抄録

Background C-reactive protein (CRP) independently predicts cardiovascular disease (CVD) and is considered to be part of metabolic syndrome (MS). The concentration of CRP are proposed to be <1.0 mg/L as low risk, 1.0 to 3.0 mg/L as intermediate risk, and >3.0 mg/L as high risk for CVD in Western society. Methods and Results Apparently healthy 179 men and 166 women were categorized with modified National Cholesterol Education Program Adult Treatment Panel III criteria (body mass index ≥25 in place of abdominal obesity) for defining MS. The cut-off points of CRP were evaluated for both MS defined by impaired fasting glucose criteria of ≥110 mg/dl (MS110) and ≥100 mg/dl (MS100), separately by sex. The optimal cut-off point of CRP was 0.65 mg/L in all subgroups. The sensitivity and specificity of this CRP value for male MS100, female MS100, male MS110, and female MS110 were 0.650 and 0.626, 1.000 and 0.771, 0.739 and 0.609, and 1.000 and 0.756, respectively. Conclusions The optimal cut-off point of CRP for MS might be 0.65 mg/L in Japan and this value can be useful in routine clinical practice and studies on MS. (Circ J 2006; 70: 384 - 388)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 70 (4), 384-388, 2006

  一般社団法人 日本循環器学会

キーワード

• Cardiovascular risk factors
• C-reactive protein
• Insulin resistance
• Metabolic syndrome

詳細情報

• CRID: 1390282680079444992
• NII論文ID: 110004497222
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.70.384
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• Web Site: https://www.jstage.jst.go.jp/article/circj/70/4/70_4_384/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007049596
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可