Comparative Oral Toxicity of Coenzyme Q10 and Its (2Z)-Isomer in Rats: Single and Four-Week Repeated Dose Toxicity Studies

• HATAKEYAMA Shigeki

  Nisshin Kyorin Pharmaceutical Co., Ltd.

• KAWASE Shigeo

  Nisshin Kyorin Pharmaceutical Co., Ltd.

• YOSHIMURA Ikuo

  Nisshin Pharma Inc

抄録

It has been reported that coenzyme Q₁₀ (CoQ₁₀) functions as an electron transfer carrier in mitochondria, and can produce an improvement in heart diseases such as congestive heart failure. Its (2Z)-isomer contains a cis-double bond at the 2-position of the decaprenyl side chain. As the original organic industrial synthesis of CoQ₁₀ resulted in a product that contained a small amount of this isomer, the efficacy and safety of CoQ₁₀ was determined using CoQ₁₀ containing this isomer; however, no toxicity data have been reported for the (2Z)-isomer itself. Thus, we conducted single (2,000 mg/kg) and 4-wk repeated (1,000 mg/kg) oral dose toxicity studies in rats to compare the toxicological profiles of CoQ₁₀ and its (2Z)-isomer. The two compounds displayed similar toxicological profiles, and it was concluded that neither CoQ₁₀ nor its (2Z)-isomer produce toxic effects in rats in single or repeated doses.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 52 (1), 9-20, 2006

  一般財団法人 学会誌刊行センター

キーワード

• coenzyme Q₁₀
• CoQ₁₀
• CoQ10
• ubiquinone
• ubidecarenone

詳細情報

• CRID: 1390001206325620736
• NII論文ID: 110004656455
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.52.9
• COI: 1:CAS:528:DC%2BD28XisFKqsLg%3D
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 7834285
• Web Site: http://id.ndl.go.jp/bib/7834285
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7834285
• Web Site: https://search.jamas.or.jp/link/ui/2007045726
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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