Gly395Arg Polymorphism of PPARα Gene Was Not Detected in Japanese Population of 729 Individuals
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- KAMEI Yasutomi
- National Institute of Health and Nutrition Tokyo Medical and Dental University
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- SAITO Kyoko
- National Institute of Health and Nutrition National Institute of Public Health
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- YOKOYAMA Tetsuji
- National Institute of Public Health
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- YOSHIIKE Nobuo
- National Institute of Health and Nutrition
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- EZAKI Osamu
- National Institute of Health and Nutrition
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- TANAKA Heizo
- National Institute of Health and Nutrition
書誌事項
- タイトル別名
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- Gly395Arg Polymorphism of PPAR.ALPHA. Gene Was Not Detected in Japanese Population of 729 Individuals
- Gly395Arg Polymorphism of PPAR アルファ Gene Was Not Detected in Japanese Population of 729 Individuals
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抄録
Peroxisome proliferator-activated receptor α (PPARα) is a member of the nuclear receptor superfamily and participates in the regulation of key proteins involved in lipid metabolism, fatty acid oxidation, homeostasis, and inflammation. Several polymorphisms of the human PPARα gene, such as Leu162Val polymorphism and Val227Ala polymorphism, have been described in different races. Recently, another PPARα polymorphism Gly395Arg polymorphism has been reported in Caucasian and African subjects. Using the Invader assay, we searched for this polymorphism in 729 Japanese adults randomly selected in a rural population. Although the synthesized oligonucleotides of each polymorphism could be distinguished clearly, all 729 individuals had the Gly (G) allele and none had the Arg (C) allele. These data suggest that there is racial variability in the frequencies of PPARα gene polymorphisms.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 52 (1), 75-78, 2006
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詳細情報 詳細情報について
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- CRID
- 1390001206325606656
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- NII論文ID
- 110004656464
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD28XisFKqsbs%3D
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 7834378
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可