周産期の牛乳腺における副甲状腺ホルモン関連蛋白質(PTHrP)mRNAの発現

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献2件 参考文献29件
  • ONDA Ken
    Laboratory of Internal Medicine III, Azabu University School of Veterinary Medicine
  • MATSUKI Naoaki
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • ONO Kenichiro
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • WADA Yasunori
    Laboratory of Internal Medicine III, Azabu University School of Veterinary Medicine

書誌事項

タイトル別名
  • Expression of Parathyroid Hormone-Related Protein (PTHrP) mRNA in Mammary Gland of Periparturient Cows

この論文をさがす

抄録

The expression of parathyroid hormone-related protein (PTHrP) mRNA was examined in mammary gland with or without lactation, and during periparturient period in a Holstein cow and a Jersey cow. In the lactating mammary gland, PTHrP was detected in alveolar epithelial cells and the lumen by immunohistochemical analysis. The relative expression levels of PTHrP mRNA in mammary gland from lactating cows were significantly higher than those from non-lactating cows (P<0.05). During periparturient period, relative PTHrP mRNA level was remarkably low before the parturition in a Jersey and a Holstein cow, however, both levels were gradually increased and reached a peak level at 5-6 weeks after the parturition. In addition, the peak level in a Jersey cow was approximately 3-fold higher than that in a Holstein cow. From these results, PTHrP was synthesized and secreted in alveolar epithelial cells in mammary gland and increased subsequently with the lactation, suggesting a possible mechanism for the regulation of local calcium homeostasis.<br>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (29)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ