Effects of Sugar Cane Extract on Pseudorabies Virus Challenge of Pigs

• LO Dan-Yuan

  Graduate Institute of Veterinary Pathology, National Chung Hsing University Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University Department of Veterinary Medicine, National Chia Yi University

• CHIEN Maw-Sheng

  Graduate Institute of Veterinary Pathology, National Chung Hsing University

• YEH Kuang-Sheng

  Graduate Institute of Veterinary Pathology, National Chung Hsing University Division of Microbiology and Immunology, Department of Medicine, Taipei Medical University

• KOGE Kenji

  Chigasaki Laboratory, Shin Mitsui Sugar Co., Ltd.

• LIN Cheng-Chung

  Graduate Institute of Veterinary Pathology, National Chung Hsing University

• HSUAN Shih-Ling

  Graduate Institute of Veterinary Pathology, National Chung Hsing University

• LEE Wei-Cheng

  Graduate Institute of Veterinary Pathology, National Chung Hsing University

抄録

This experiment aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection. Twelve-week-old experimental pigs were fed with SCE (500 mg/kg of body weight per day) for 3 days and challenged with PrV (2 × 10⁵ TCID₅₀) on the second day. Pigs that were only challenged with PrV and without SCE-treatment served as controls. The leukocyte functional assays were performed on the 7th and 14th day post-PrV challenge. Our results showed a significant enhancement (P<0.05) of natural killer cytotoxicity, lymphocyte proliferation, phagocytic function of monocytes, and interferon-gamma (IFN-γ) production of CD4⁺ and γδ T cells in the SCE-treated pigs compared with the controls. In addition, SCE administration reduced the severity of clinical signs and brain lesion in the course of disease in PrV-challenged pigs. SCE-treated pigs showed a 12% growth enhancement compared with untreated controls. SCE administration had an immunostimulating effect on porcine immunity that may subsequently enhance protective activities against PrV infection which may be extensively applied in field for the prevention of infections.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 68 (3), 219-225, 2006

  公益社団法人 日本獣医学会

キーワード

• immunomodulation
• interferon-gamma
• leukocyte function
• pseudorabies
• sugar cane extract

詳細情報

• CRID: 1390282681403174528
• NII論文ID: 110004675728
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.68.219
• COI: 1:STN:280:DC%2BD287pt12hsA%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 7900409
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7900409
• Web Site: http://www.jstage.jst.go.jp/article/jvms/68/3/68_3_219/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006124755
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可