猫GADD45遺伝子クローニングと猫リンパ腫細胞株における変異解析

• OIKAWA Tatsuo

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• OKUDA Masaru

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• KANEKO Naoki

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• WATANABE Malaika

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• HIRAOKA Hiroko

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• ITAMOTO Kazuhito

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• NAKAICHI Munekazu

  Laboratory of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University

• MIZUNO Takuya

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• INOKUMA Hisashi

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

書誌事項

タイトル別名

• Cloning of the Feline GADD45 cDNA and Analysis of its Mutation in Feline Lymphoma Cell Lines

抄録

Growth arrest and DNA damage-inducible protein 45 (GADD45) plays an important role in suppressing multistep carcinogenesis. In this report, we describe the isolation of the complete wild-type feline GADD45 cDNA from feline tissues. Expression of feline GADD45 mRNA was detected in the liver, spleen, kidney, lung, and testis. The predicted amino acid sequences encoded by the full-length feline GADD45 cDNA display sequence homology with those from other vertebrates, and as in the case of human GADD45, cell growth suppression was observed by ectopic expression of feline GADD45. However, no mutations were detected by sequence analysis of feline GADD45 in several feline lymphoma cell lines, indicating that the GADD45 mutation might be uncommon in feline oncogenesis.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 68 (3), 297-301, 2006

  公益社団法人 日本獣医学会

キーワード

• feline
• GADD45
• P53

詳細情報

• CRID: 1390001206426303744
• NII論文ID: 110004675743
• NII論文ID: 130000447940
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.68.297
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 7901010
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030733382
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7901010
• Web Site: http://www.jstage.jst.go.jp/article/jvms/68/3/68_3_297/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006124762
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可