MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma
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Mucin core protein expression in ulcerative colitis-associated colorectal carcinoma (UC-CRC) has not been investigated to date. We immunohistochemically examined expression of MUC2, MUC5AC, and MUC1 mucin core proteins in 8 UC-CRCs (4 mucinous carcinomas and 4 well and/or moderately differentiated adenocarcinomas) in order to characterize their mucin phenotypes. We then compared these with sporadic colorectal carcinomas (sporadic CRCs) (30 mucinous carcinomas and 60 well and/or moderately differentiated adenocarcinomas) in order to confirm whether any specific cellular lineage differentiation occurs in UC-associated carcinogenesis. MUC2, MUC5AC, MUC1 are normally synthesized in goblet cells of gastrointestinal tract, in gastric foveolar epithelium, and in columnar and goblet cells of the colorectum, respectively. UC-CRC exhibited extensive expression of MUC2 (50-100%), MUC5AC (50-75%), and MUC1 (75%), irrespective of histological type, and MUC2+/MUC5AC+/MUC1+ was the most common mucin phenotype (4/8). Six of 8 UC-CRCs had the MUC2+ phenotype, and co-expression of MUC5AC or MUC1 was demonstrated in 5 of these. These findings were similar to those of sporadic mucinous CRCs. The present results indicate that both UC-CRCs and sporadic mucinous CRCs are predominated by cancer cells of goblet cell lineage (MUC2+) with gastric differentiation (MUC5AC+), and up-regulation of gelforming mucin MUC2 and MUC5AC would account for the frequently observed mucinous histology. This suggests that UC-associated carcinogenesis may originate from MUC5AC+ gastric metaplasia and is similar to UACL (ulcer-associated cell lineage) generated in colorectal mucosa exhibiting long-term chronic inflammation.
収録刊行物
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- Acta medica et biologica
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Acta medica et biologica 52 (1), 21-27, 2004-03
Niigata University School of Medicine
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詳細情報 詳細情報について
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- CRID
- 1050001339228393472
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- NII論文ID
- 110004689998
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- NII書誌ID
- AA00508361
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- ISSN
- 05677734
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- HANDLE
- 10191/1834
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- CiNii Articles