Reduced Fibrinolytic Activity in Aqueous Humor of Chronic Simple Glaucoma

  • MEHRA K. S.
    Department of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University
  • DUBE B.
    Department of Pathology, Institute of Medical Sciences, Banaras Hindu University
  • MIKUNI Ikuo
    Department of Ophthalmology, School of Medicine, Tokai University
  • DUBE R. K.
    Department of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University

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Fibrinolytic activity of aqueous humor was tested by the Astrup fibrin plate lysis technique in 7 patients who had chronic simple glaucoma and was compared with a control group of 7 patients with senile cataract. The plasminogen activator content of aqueous humour in glaucoma patients was remarkably reduced; it was not desmonstrable in as many as six out of seven patients. The lysis zones in the control group ranged from 110 to 900mm^2 with an average of 423mm^2. The want of aqueous fibrinolytic activity may have a pathogenetic implication for galucoma since deposition of fibrin in the angle of the eye to depressed fibronolytic activity could increase resistance to aqueous flow.

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