Effects of Adenosine on Cholinergic Transmission in Mammalian Vesical Parasympathetic Ganglia
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- NISHIMURA Toshihiko
- Department of Physiology, Tokai University School of Medicine
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Intracellular recordings were made from mammalian vesical parasympathetic ganglia. A fast excitatory postsynaptic potential (EPSP) was abolished by hexamethonium (200 μM) in rabbit and feline ganglia. A slow inhibitory postsynaptic potential (IPSP) and a following slow EPSP were abolished by atropine (1 μM) in the feline ganglia. Bath application of adenosine (300 μM) depressed the amplitude of nicotinic fast EPSP by 48±4% in the rabbit ganglia. The action of adenosine was dose-dependent An antagonist of A1-purinoceptors, 8-cyclopentyltheophylline (1-10μM), inhibited the adenosine-induced depression but not the amplitude of fast EPSP. Adenosine (2-3mM) did not significantly affect either the muscarinic slow IPSP, or the slow EPSP, in the feline ganglia. Adenosine also caused a hyperpolarization (1-5 mV) in 40% of the rabbit neurons and 66% of the feline neurons. However a purinergic IPSP was not recorded from either species. These data suggest diverse actions of adenosine in modulating cholinergic transmission in rabbit and feline vesical ganglia.
収録刊行物
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- Tokai journal of experimental and clinical medicine
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Tokai journal of experimental and clinical medicine 22 (1), 1-5, 1997-03
東海大学
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詳細情報
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- CRID
- 1570009752060999552
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- NII論文ID
- 110004700113
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- NII書誌ID
- AA00863975
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- ISSN
- 03850005
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles