歯周疾患に対する含嗽剤LA-1の臨床効果  [in Japanese] Clinical Effect of LA-1 Gargle in Periodontal Disease  [in Japanese]

3種の生薬を主成分としたペーストタイプの歯肉炎,歯周炎治療薬「アセス」と同一処方である含嗽剤LA-1の歯周疾患に対する臨床的検討を行った。臨床所見および各種診査により歯肉炎,歯周炎と診断された96症例を対象とした。ブラッシングは患者が従来行っていた方法で歯磨剤を使用しないで行わせ,ブラッシング終了後本剤を1日,朝,夕2回4週間使用させ以下の結果を得た。1.歯肉炎の諸症状に対して改善が認められ有効率は92.3%であった2.歯周炎の諸症状に対して改善が認められ有効率は2週目で55.7%,4週目で77.1%であった。3.試験期間中LA-1が原因と考えられる副作用は1例も認められなかった。4.LA-1の歯周疾患に対する効果が認められ,一般用医薬品として有用な薬剤であると考えられた。

Clinical investigations were conducted on the effect on periodontal disease of LA-1 gargle, prescribed the same as "Acess", a paste used to treat gingivitis and marginal periodontitis, containing as principal components three kinds of medicinal herbs. The subjects consisted of 96 patients diagnosed with gingivitis or marginal periodontitis on the basis of clinical findings and other examinations. Each patient brushed his teeth without dentifrice the same way as before, and after that was given LA-1 gargle every morning and evening for 4 weeks. The results were as follows. 1. Inflammation in ingivitis was improved, and the efficacy rate of this agent was 92.3%. 2. Inflammation in marginal periodontitis was improved, and the effdcacy rate of this agent was 55.7% as of 2 weeks and 77.1% as of 4 weeks. 3. No side effects which seemed to be attributable LA-1 occurred during the period of the experiment. 4. An effect of LA-1 on periodontal disease was demonstrated. LA-1 is considered to be an effective agent as a proprietary drug.