ヒト歯肉線維芽細胞に対する免疫抑制剤（ＦＫ５０６，Ｃｉｃｌｏｓｐｏｒｉｎ）の影響

• 加藤 孝

  日本大学歯学部保存学教室歯周病学講座

書誌事項

タイトル別名

• Effect of Immunosuppressant Drug(FK506 and Ciclosporin) on Gingival Fibroblasts.

抄録

Ciclosporin (Cs) is a widely prescribed drug for patients who have undergone organ transplants. One of its side effects is the induction of gingival overgrowth. The clinical and histopathological features of Cs-induced gingival overgrowth have been described, FK 506 (FK), another immunosuppressant, has also been used recently for organ transplantation. But no reports have been made on its side effects on human gingiva. In order to discover whether FK also induces gingival overgrowth, the effects of FK and Cs on human gingival fibroblasts were compared and the possible role of interleukin-1 (IL-1) in immunosuppressant-induced gingival overgrowth was analyzed. The effects of FK and Cs on [14C] proline incorporation, collagen production, collagenase activity and collagenase inhibitor activity were investigated. FK appeared to have most potent dose-dependent stimulative effects than Cs on [14C] proline incorporation, collagen production and collagenase inhibitor activity. The presence of both FK and IL-1 in the culture medium significantly stimulated [ 14 C] proline incorporation and collagen production by fibroblasts in comparison with use of the agent alone. These results indicate that FK may induce gingival overgrowth and that IL-1 may be an important co-factor in the pathogenesis of immunosuppressant-induced gingival overgrowth.

収録刊行物

• 日本歯周病学会会誌

  日本歯周病学会会誌 37 (2), 211-223, 1995

  特定非営利活動法人 日本歯周病学会

キーワード

• 歯肉増殖
• FK 506
• シクロスポリン
• インターロイキン1
• 歯肉線維芽細胞

詳細情報

• CRID: 1390282679387298432
• NII論文ID: 110004726081
• NII書誌ID: AN0019129X
• DOI: 10.2329/perio.37.211
• ISSN: 1880408X
• ISSN: 03850110
• Web Site: https://search.jamas.or.jp/link/ui/1996070367
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可