茶葉成分含有含嗽剤のプラーク形成,歯肉炎進行ならびに口臭抑制に対する効果について  [in Japanese] Effect of an Oral Rinse Extracted from Green Tea on Plaque Formation, Gingivitis and Halitosis  [in Japanese]

茶葉の可溶成分であるカテキン類を含む含嗽剤は,化学的プラークコントロールとして,実験的歯肉炎発症の予防効果があると報告されている。そこでカテキン含有含嗽剤単独使用によるプラーク形成抑制,歯肉炎の進行抑制ならびに口臭抑制効果について検討した。被験者は全身的疾患のない22歳から48歳までの成人42名とした。試験7日前に臨床検査と共に口腔内のプラークおよび歯石を除去した。試験開始前7日間は通常のブラッシングを行った。カテキン群は茶カテキン1.0%含有含嗽剤を,コントロール群はカテキンから茶エキスのみを除いた含嗽剤を使用した(1日3回10ml,30秒間含嗽)。試験開始後7日間は機械的プラークコントロールを中止させ,含嗽のみとした。2種類の含嗽剤使用は二重盲検法で行った。臨床パラメーター(PlI, GI, GCF,口臭)およびポケット内細菌の採取は試験0, 3, 7日目に行った。その結果,茶カテキン含有含嗽剤は口臭の抑制効果を示した。PlI, GI, GCFはカテキン群の方が低い値を示したが,統計学的有意差を認めず,茶カテキン含有含嗽剤はプラーク形成の抑制,歯肉炎の進行抑制についてはその傾向を示すのみであった。

It has been reported that oral rinses extracted from green tea, which include catechin as a soluble ingredient for chemical plaque control, was effective in preventing experimental gingivitis in man. The purpose of this study was to investigate the effectiveness of an oral rinse containing 0.25% catechin for prevention of plaque formation, gingivitis and halitosis. The subjects were 42 adult volunteers ranging in age from 22 to 48 years without any relevant medical or pharmacotherapy histories. Seven days before each study period, the volunteers underwent removal of plaque and calculus. The subject then requested to refrain from their normal hygiene methods for 7 days. In the catechin group, the subjects were asked to rinse with 10ml of mouthrinse containing 1.0% green tea extract (catechin). In the control group, the subjects used mouthrinse for which tea extract components except for catechin were eliminated. Both groups rinsed for 30s three times a day for 7 days. The subjects were not allowed to use a toothbrush or other cleaning devices during the study periods. This results were assessed using a double-blind, two mouth rinses cross-over design balanced for the 1st and 2nd periods. Clinical parameters (Plaque Index (PlI), Gingival Index (GI), gingival crevicular fluid level (GCF) and halitosis) were determined and microbiological samples were collected at the baseline, at 3 and 7 days after the start of the study. The oral rinse containing Japanese tea extract was found to be useful for prevention of halitosis. PlI and GI scores and GCF value in the catechin group were lower than in the control group during the study period. However, plaque formation and gingivitis were not significantly different between the catechin and control groups.