筋収縮における乳酸の役割

• 和田 正信

  広島大学総合科学部

• 三島 隆章

  広島大学大学院生物圏科学研究科

• 山田 崇史

  広島大学大学院生物圏科学研究科

書誌事項

タイトル別名

• The role of lactic acid in muscle contraction
• キンシュウシュク ニ オケル ニュウサン ノ ヤクワリ

抄録

Repeated intense skeletal muscle contraction leads to a progressive loss of force-generating capacity. This decline in function is generally referred to as muscular fatigue. Since the work of Fletcher and Hopkins (1907), it has been known that fatigued muscles accumulate lactic acid. Intracellular acidosis due to lactic acid accumulation has been regarded as the most important cause of fatigue during intense exercise. Recent challenges to the traditional view, however, have suggested that lactic acid plays a role in muscle contraction distinct from that implied by earlier studies. This brief review presents (1) a short history of our understanding about lactic acid that explains the early acceptance of a causal relationship between lactic acid and fatigue, (2) evidence to show the temperature dependence of acidosis-induced changes and the beneficial effect of acidosis, and (3) a proposal that lactate production retards, not causes, acidosis. These findings require us to reevaluate our notions of lactic acid, acidosis and muscular fatigue.

収録刊行物

• 体育学研究

  体育学研究 51 (3), 229-239, 2006

  一般社団法人 日本体育・スポーツ・健康学会

キーワード

• 乳酸塩
• 乳酸性アシドーシス
• 温度
• pH

詳細情報

• CRID: 1390282679077506688
• NII論文ID: 110004731807
• NII論文ID: 130004489511
• NII書誌ID: AN00409623
• DOI: 10.5432/jjpehss.51.229
• ISSN: 18817718
• ISSN: 04846710
• NDL書誌ID: 7989161
• Web Site: http://ir.lib.hiroshima-u.ac.jp/00026280
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7989161
• Web Site: https://search.jamas.or.jp/link/ui/2006254023
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可