Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues

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  • Heikinheimo Kristiina
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku Department of Oral Diseases, Turku University Central Hospital
  • Mori Kazuhisa
    2<sup>nd</sup> Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Dentistry at Niigata
  • Nagatsuka Hitoshi
    Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Happonen Risto-Pekka
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku Department of Oral Diseases, Turku University Central Hospital

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タイトル別名
  • Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues
  • Transforming Growth Factor Beta TGF ベータ Gene Family Members in Developing and Neoplastic Odontogenic Tissues

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During the last decade, several molecules regulating tooth development have been identified (http://bite-it.helsinki.fi/). Especially members of the transforming growth factor beta (TGF-β) supergene family, structurally relates cytokines, are essential for teeth to develop. These include TGF-βs, activin A, bone morphogenetic proteins (BMPs), and their cell surface receptors. In addition, follistatin, an extracellular protein that interacts with activin and BMP signalling, appears to be an important mediator of associated inductive signals. Enhanced or impaired TGF-β/BMP signalling may play a role in odontogenic tumorigenesis. This review focuses on findings of our studies on the roles played by of TGF-β receptors, their ligands and extracellular modifiers during tooth development and in odontogenic tumours.

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