Combined Treatment Effects of Irradiation and SN－38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197

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  • ヒト腫瘍培養細胞株PECA4197に対する放射線およびSN－38（カンプトテシン誘導体イリノテカン活性代謝物）併用効果
  • ヒト シュヨウ バイヨウ サイボウカブ PECA4197 ニ タイスル ホウシャセン オヨビ SN-38 カンプトテシン ユウドウタイ イリノテカン カッセイ タイシャブツ ヘイヨウ コウカ

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The in vitro combined effects of irradiation and SN－38, an active metabolite of irinotecan, on the human squamous cell carcinoma cell line PECA4197 derived from a head and neck carcinoma were examined．Exponentially growing cell cultures were pretreated with SN-38 for 90 min, in the concentration of 0.005 and 0.5μg/ml, respectively，and then irradiated. As a control, cells without pretreatment were also irradiated. The cell survival rate was determined using a conventional clonogenic survival assay. The enhanced effects of radiation-induced cell killing, depending upon the concentration of SN-38, were presented with a decrease of shoulder part or extrapolation number (n) of survival curve, corrected for the cytotoxicity of SN-38 alone. The value of D0 was unchanged after SN-38 pretreatment. These results suggested that the pretreatment with SN-38 inhibited potentially lethal damage repair in the cell line, leading to the potentiation of irradiation effects．

弘前医学. 51(1), 1999, p.10-14

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  • 弘前医学

    弘前医学 51 (1), 10-14, 1999-08-31

    弘前大学医学部・弘前医学会

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