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- SATO Itaru
- Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University
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- KOFUJITA Hisayoshi
- Laboratory of Forest Product Chemistry, Faculty of Agriculture, Iwate University
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- SUZUKI Tadahiko
- Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Iwate University
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- KOBAYASHI Haruo
- Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Iwate University
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- TSUDA Shuji
- Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Antiinflammatory Effect of Japanese Horse Chestnut (Aesculus turbinata) Seeds
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抄録
The antiinflammatory effects of Japanese horse chestnut (Aesculus turbinata) seeds were examined in vivo and in vitro. The extract of this seed (HCSE) inhibited croton oil-induced swelling of the mouse concha. HCSE inhibited cyclooxygenase (COX) -1 and -2 activities, but had no effect on 15-lipoxygenase and phospholipase A2 activities. Inhibition of COX-2 occurred at a lower concentration of HCSE than for COX-1. Japanese horse chestnut seeds contain coumarins and saponins, but these chemicals did not inhibit COX activities. These results suggest that the antiinflammatory effect of Japanese horse chestnut seeds is caused, at least partly, by the inhibition of COX. The inhibitor of COX in this seed may be a chemical(s) other than coumarins and saponins.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 68 (5), 487-489, 2006
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424319872
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- NII論文ID
- 110004775652
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 7975635
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可