Immunity of Chicks Against Colibacillosis by Vaccination of Parent Breeders

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Abstract

To study in ovo transfer of immunity against Escherichia coli infection, three groups of hens were injected with different vaccines composed of E. coli components, including one experimental pilus vaccine and two commercial vaccines. Increases of specific antibodies to type 1 pili and lipopolysaccharides were found in vaccinated hens. Chicks hatched from eggs collected from vaccinated hens were examined for antibodies and challenged with virulent E. coli at 21 days of age; immunity was judged according to mortality and lesions of colisepticemia at 4 days after challenge. Chicks from vaccinated hens had low or no mortality, mild gross lesions in viscera, and hyperplasia of splenic lymphoid tissue. Chicks from unvaccinated hens had significantly greater gross lesions. Results of this study indicate that inoculation of laying hens with antigens of E. coli leads to immunity in chicks that is highly protective at 3 weeks of age.

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