Effect of Apolipoprotein E Genotype on Association of Menopausal Status with Lipid Level in Japanese Women

• Yamanouchi Yasuko

  Department of Hygiene and Public Health, Teikyo University School of Medicine

• Hashimoto Hideki

  Department of Hygiene and Public Health, Teikyo University School of Medicine

• Yamaoka Kazue

  Department of Hygiene and Public Health, Teikyo University School of Medicine

• Takano Takako

  Department of Hygiene and Public Health, Teikyo University School of Medicine

• Kisaki Tomonari

  Division of Health Care, Store of Yokohama, Takashimaya Company, Ltd.

• Oku Junji

  Group of Employee Health Management, Mitsui Mutual Life Insurance Company

• Yano Eiji

  Department of Hygiene and Public Health, Teikyo University School of Medicine

抄録

Serum lipid level increases during hormonal transition before and after menopause. In Caucasians, changes in lipid level after menopause across apolipoprotein E (apo E) genotypes were studied. We investigated 159 Japanese healthy female workers (age range, 35-63). The apo E genotypes were determined by the polymerase chain reaction single-strand conformation polymorphisms method for the entire apo E-coding region. The low-density lipoprotein cholesterol (LDL-cholesterol) level significantly varied according to the apo E genotype, but not according to the menopausal status after adjusting for age and body mass index (p < 0.001). The effect of menopause on LDL-cholesterol level significantly varied depending on the apo E genotype (p < 0.05). Apo E2 [APOE, R158C] carriers in the senium period had a lower LDL-cholesterol level than those in the fertile period (81.5 ± 12.0 mg/dl vs. 122.3 ± 12.9 mg/dl). In contrast, apo E3 homozygotes in the senium period showed a higher LDL-cholesterol level than those in the fertile period (140.9 ± 7.0 mg/dl vs. 134.1 ± 6.1 mg/dl). The LDL-cholesterol levels of apo E4 [APOE, C112R] carriers were the similar for the two periods. These results indicate that the serum lipid control in perimenopausal women should be customized according to the apo E genotype for the promotion of women's health in Japan. <br>

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 52 (5), 532-539, 2006

  公益社団法人 日本薬学会

キーワード

• menopause
• lipid levels
• apolipoprotein E genotype
• polymerase chain reaction-single strandard conformation polymorphism
• Japanese women
• low-density lipoprotein cholesterol

詳細情報

• CRID: 1390001204497647744
• NII論文ID: 110004809607
• NII書誌ID: AA11316464
• DOI: 10.1248/jhs.52.532
• COI: 1:CAS:528:DC%2BD28XhtFKltLnE
• ISSN: 13475207
• ISSN: 13449702
• NDL書誌ID: 8073314
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8073314
• Web Site: http://www.jstage.jst.go.jp/article/jhs/52/5/52_5_532/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007062902
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可