ロズマリン酸の抗酸化作用とラット肺組織マトリックスメタロプロチアーゼ阻害作用について  [in Japanese] Antioxidant Activity of Rosmarinic Acid Contributes to Inhibition of Matrix Metalloproteinase Activity in Rat Lung  [in Japanese]

Rosmarinic acid is an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, being found to have a multitude of biological activities such as anti-inflammation, antimutagen and antioxidant. In order to establish the relationship between antioxidants and matrix metalloproteinase (MMP) -inhibitory activity, rosmarinic acid and caffeic acid were evaluated for their potential in 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and blocking of MMP activity. Gelatinase activity was measured using the gelatin degradation and/or gelatin-zymography assay. From comparison of the different levels of DPPH radical scavenging activity, it was deduced that a crucial role in inhibition for MMP activity might play by an antioxidant activity. This comparative study is proposed as a basis for designing the enhanced antiproteolytic activities, and no or reduced side effects for use in hindering inflammation, cancer invasion or metastasis and angiogenesis in lung.