Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease

• Sun Quan-Zhong

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• Chen Dao-Feng

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• Ding Pei-Lan

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• Ma Chao-Mei

  Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University

• Kakuda Hiroko

  Laboratory of Chemistry, Toyama Medical and Pharmaceutical University

• Nakamura Norio

  Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• Hattori Masao

  Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

抄録

Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC₅₀ values of 50 and 20 μM, respectively.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 54 (1), 129-132, 2006

  公益社団法人 日本薬学会

キーワード

• longipedunin
• <i>Kadsura longipedunculata</i>
• HIV-1 protease
• lignan
• X-ray crystal structure

詳細情報

• CRID: 1390001204168281984
• NII論文ID: 110004820341
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.54.129
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7756870
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7756870
• Web Site: http://www.jstage.jst.go.jp/article/cpb/54/1/54_1_129/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006310038
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可