マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響

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  • The effects of Co-PCB in allergic disorder: Analyses of mast cell functions in response to Co-PCB.(Research Group 5)

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PCBの免疫系に及ぼす影響のメカニズムには異なるシグナル伝達系の間でのクロストークがその一つの要因である可能性が強く示唆された。

In our previous report, we showed that Co-PCB does not involve directly immune-response through both degranulation and TNF-α release in mast cells. However the influences of immune system due to Co-PCBs are well-known. Therefore we examined the effect of co-PCB in innate immunity which is thought important rule as immune response in mast cell. BMMC pre-treated with co-PCB did not expressed TNFα mRNA, although BMMCs stimulated with LPS or co-PCB were expressed TNFα and CYP1A1 mRNA, respectively. Our result suggests that one of functions as immune-suppression by co-PCB is cross-talking between the differential signaling.

麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ5

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