Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds

• Harinantenaina Liva

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Tanaka Michi

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Takaoka Shigeru

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Oda Munehiro

  Food Functionality Research Institute, Division of Research and Development, Meiji Dairies Corporation

• Mogami Orie

  Food Functionality Research Institute, Division of Research and Development, Meiji Dairies Corporation

• Uchida Masayuki

  Food Functionality Research Institute, Division of Research and Development, Meiji Dairies Corporation

• Asakawa Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

抄録

Bioguided fractionation of the methanol extract of Momordica charantia dried gourds led to the isolation of three new cucurbitane triterpenoids (1—3), together with eight known compounds (4—11). The aglycone of momordicoside I was isolated from the ether soluble fraction in a high amount. The structures of the metabolites were established on the basis of one and two dimensional NMR spectroscopic evidence, X-ray analysis, and comparison with the reported data in the literature. A number of phytochemicals have been isolated from Momordica charantia but the constituents responsible for the hypoglycaemic/antihyperglycaemic activities have not been determined. Therefore, in order to evaluate the contribution of the cucurbitane triterpenoids of the ether fraction of M. charantia methanol extract to in vivo anti-diabetic effects, the major compounds, 5β,19-epoxy-3β,25-dihydroxycucurbita-6,23(E)-diene (4), and 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (5) have been tested and have shown blood hypoglycaemic effects in the diabetes-induced male ddY mice strain at 400 mg/kg. The two aglycones of charantin did not show any hypoglycaemic effects. Our finding is the first demonstration that major pure cucurbutanoid compounds of M. charantia have in vivo hypoglycaemic effects.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 54 (7), 1017-1021, 2006

  公益社団法人 日本薬学会

キーワード

• <i>Momordica charantia</i>
• Cucurbitaceae
• cucurbitane
• antidiabetic
• ddY mice

詳細情報

• CRID: 1390001204169577088
• NII論文ID: 110004836426
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.54.1017
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7960607
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7960607
• Web Site: http://www.jstage.jst.go.jp/article/cpb/54/7/54_7_1017/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006256402
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可